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She is the author of Women Who Would Be Rabbis: A History of Women's Ordination, 1889-1985 (Beacon Press, 1998), which was a finalist for the National Jewish Book Award and a main selection of the Jewish Book Club, and Conservative Judaism in America: A Biographical Dictionary and Sourcebook (1988). She has edited American Jewish Women's History: A Reader (2003) and, with Jonathan D. Sarna, Women and American Judaism: Historical Perspectives (2001), and is co-author of Three Hundred and Fifty Years: An Album of American Jewish Memory (2005).

She has won accolades for teaching from both Ohio State University and American University; research fellowships from the American Jewish Archives and the Memorial Foundation for Jewish Culture; and received the Anti-Defamation League Community Leadership Award (1995) and American University's Faculty Award for Outstanding Contributions to Academic Development (1997) for her work in pioneering the teaching of African-American/Jewish Relations at American University and Howard University.

Prof. Nadell chaired the Academic Council of the American Jewish Historical Society, is book review editor of the journal American Jewish History, and is a member of many academic advisory boards. She was deeply involved in the array of activities celebrating the 350th anniversary of Jewish life in America, and presented more than forty public lectures marking that event. Her consulting work for museums includes the Library of Congress and the new National Museum of American Jewish History.

She teaches a wide variety of courses in Jewish history, including Ancient and Medieval Jewish Civilization, Modern Jewish Civilization, American Jewish History, American Jewish Women's History, Holocaust, and History of Israel; and works with graduate students in modern Jewish history.